Adrenocorticotropic Hormone(1-4)/ACTH(1-4)/19405-50-6/Peptide synthesis

PeptideName：Adrenocorticotropic Hormone(1-4)/ACTH(1-4)/19405-50-6/Peptide synthesis

Catalog No：GT-M2921

Sequence：H-Ser-Tyr-Ser-Met-OH

CAS Number：19405-50-6

Molecular Formula：C20H30N4O8S1

Molecular Weight：486.54

Category：Adrenocorticotropic Hormone(1-4),ACTH(1-4),19405-50-6,Peptide synthesis,Peptide raw material company

Description：ACTH is a 39-peptide hormone secreted by the anterior pituitary gland. It is derived from the cleavage product of pro-melanocortin (POMC). Its core function is to activate the melanocortin-2 receptor (MC₂) in the adrenal cortex, regulating cortisol synthesis and secretion. It also has anti-inflammatory and immunomodulatory activities. ACTH (1-4), as its N-terminal fragment, retains some structural features, but its biological activity differs significantly from that of the complete hormone.

Specifications

Apperance: White to off-white powder

Purity(HPLC): ≥98.0%

Single Impurity: ≤2.0%

Acetate Content(HPLC): 5.0%～12.0%

Water Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

Packing and Shipping: Low temperature, vacuum packing, accurate to mg as required.

FAQ：

Which end is best for my research?

By default, the peptide ends with an N-terminal free amino group and a C-terminal free carboxyl group. The peptide sequence often represents the sequence of the mother protein. In order to be closer to the mother protein, the end of the peptide often needs to be closed, that is, n-terminal acetylation and C-terminal amidation. This modification avoids the introduction of excess charge, and also makes it more able to prevent exonucliase action, so that the peptide is more stable.

What problems should be paid attention to in the storage process?

The peptide you received was packaged in lyophilized powder. Peptides are hydrophilic, and absorption of water will reduce the stability of the peptide and reduce the peptide content. Please pay attention to the following: first, with desiccants, stored in a dry environment. Second, once received, please immediately put into the freezer -20℃ storage, in order to maintain maximum stability. Third, avoid the use of no automatic frost function of the freezer. Changes in humidity and temperature can affect the stability of peptides. Fourth, the external temperature during transportation does not affect the validity and quality of peptides.

If you want to do a biotin modification at the N terminal, do you need to put a gap between the biotin and the peptide sequence?

The standard biotin labeling procedure used by our company is to attach an Ahx to the peptide chain, followed by biotin. Ahx is a 6-carbon compound that acts as a barrier between the peptide and the biotin.

If a ACTH(1-4) is 98% pure, what is 2%?

Two percent of the composition was truncated or deleted sequence fragments.

Is it necessary to put a gap between the peptide and the dye?

If you are going to attach a large molecule (such as a dye) to the peptide, it is best to put a space between the peptide and the ligand to minimize interference with the receptor by the folding of the peptide itself or by the folding of its conjugate. Others do not want intervals. For example, in the folding of proteins, it is possible to determine how far apart the folding structure of an amino acid is by attaching a fluorescent dye to a particular site.