N-Ac Semax Amidate/80714-61-0/Semax Acetate
- Product Description
PeptideName：N-Ac Semax Amidate/80714-61-0/Semax Acetate
Catalog No：GT-A026
Sequence：/
CAS Number：80714-61-0
Molecular Formula：C37H51N9O10S
Molecular Weight：813.92
Category：N-Ac Semax Amidate,80714-61-0,Peptide synthesis,Peptide raw material company
Description：N-Ac Semax Amidate mediates signaling through melanocortin receptors (MC4/MC5). It does not directly activate the receptors but significantly amplifies downstream pathways: it rapidly upregulates BDNF/TrkB levels in the hippocampus, promoting neuronal survival, axonal regeneration, and synaptic plasticity; inhibits glutamate excitotoxicity, oxygen free radicals, and apoptosis, thereby alleviating brain injury; activates the dopamine and 5-hydroxytryptamine systems to regulate neurotransmitter balance; and simultaneously downregulates pro-inflammatory factors and inhibits microglial activation, exerting anti-inflammatory and immunomodulatory effects. In animal models, it improves ischemic stroke, Alzheimer’s disease, cognitive impairment, and depression-like symptoms, and enhances learning, memory, and attention. It has been approved for the clinical treatment of cerebral ischemia, cognitive impairment, and neurodegenerative diseases in regions such as Russia, and is also a core tool in global research on neuropharmacology and cognitive enhancement.
Specifications
Apperance: White to off-white powder
Purity(HPLC): ≥98.0%
Single Impurity: ≤2.0%
Acetate Content(HPLC): 5.0%～12.0%
Water Content (Karl Fischer): ≤10.0%
Peptide Content: ≥80.0%
Packing and Shipping: Low temperature, vacuum packing, accurate to mg as required.
FAQ：
How do you dissolve polypeptides?
The solubility of polypeptide depends mainly on its primary and secondary structure, the nature of modification label, solvent type and final concentration. If the peptide is insoluble in water, ultrasound can help dissolve it. For basic peptide, it is recommended to dissolve with 10% acetic acid; For acidic peptides, dissolution with 10%NH4HCO3 is recommended. Organic solvents can also be added to insoluble polypeptides. The peptide is dissolved in the least amount of organic solvent (e.g., DMSO, DMF, isopropyl alcohol, methanol, etc.). It is highly recommended that the peptide be dissolved in the organic solvent first and then slowly added to water or other buffer until the desired concentration.
Can you give some advice on the design of phosphorylated peptides?
As the length increases, the binding efficiency gradually decreases from the phosphorylated amino acid onwards. The synthesis direction is from the C terminal to the N terminal. It is recommended that the residues after the phosphorylated amino acid should not exceed 10, that is, the number of amino acid residues before the phosphorylated amino acid from the N terminal to the C terminal should not exceed 10.
How is my peptide transported? What test reports are provided?
All freeze-dried polypeptides are usually stored in special containers of 2 ml or 10ml with original analytical data and synthesis reports containing important information such as sequence, molecular weight, purity, weight, and number of the polypeptide.
If a N-Ac Semax Amidate is 98% pure, what is 2%?
Two percent of the composition was truncated or deleted sequence fragments.
How pure can the peptide be?
Our company can provide different purity levels for customers to choose from, from crude to > 99.9% purity. According to customer needs we can provide purity > 99.9% ultra-pure polypeptide.
