Setmelanotide/920014-72-8/Setmelanotide Peptide

PeptideName：Setmelanotide/920014-72-8/Setmelanotide Peptide

Catalog No：GT-L001

Sequence：Ac-Arg-c(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2

CAS Number：920014-72-8

Molecular Formula：C49H68N18O9S2

Molecular Weight：1117.309

Category：Setmelanotide,920014-72-8,Peptide synthesis,Peptide raw material company

Description：Setmelanotide (CAS 920014-72-8) is a highly selective cyclic peptide agonist of the melanocortin 4 receptor (MC4R). It can effectively cross the blood-brain barrier to act on the hypothalamic energy regulation center, exerting potent appetite suppression and energy expenditure regulation by repairing the leptin-melanocortin signaling pathway, making it an important targeted peptide drug for the treatment of hereditary obesity and related syndromes.

Specifications

Apperance: White to off-white powder

Purity(HPLC): ≥98.0%

Single Impurity: ≤2.0%

Acetate Content(HPLC): 5.0%～12.0%

Water Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

Packing and Shipping: Low temperature, vacuum packing, accurate to mg as required.

FAQ：

Which end is best for my research?

By default, the peptide ends with an N-terminal free amino group and a C-terminal free carboxyl group. The peptide sequence often represents the sequence of the mother protein. In order to be closer to the mother protein, the end of the peptide often needs to be closed, that is, n-terminal acetylation and C-terminal amidation. This modification avoids the introduction of excess charge, and also makes it more able to prevent exonucliase action, so that the peptide is more stable.

Is it necessary to put a gap between the peptide and the dye?

If you are going to attach a large molecule (such as a dye) to the peptide, it is best to put a space between the peptide and the ligand to minimize interference with the receptor by the folding of the peptide itself or by the folding of its conjugate. Others do not want intervals. For example, in the folding of proteins, it is possible to determine how far apart the folding structure of an amino acid is by attaching a fluorescent dye to a particular site.

If a Setmelanotide is 98% pure, what is 2%?

Two percent of the composition was truncated or deleted sequence fragments.

How do you determine if a peptide is looped?

We use the Ellman reaction to test whether the ring formation is complete. If the Ellman test is positive (yellow), the ring reaction is incomplete. If the test results are negative (not yellow), the ring reaction has been complete. We do not provide the analysis report of cyclization identification for our clients. Generally, there will be a description of Ellman's test results in the QC report.