Thymopentin is not common to us, because this medicine is very serious for all kinds of diseases, such as patients with malignant tumors and patients who have undergone major surgery, and there is no need for small problems such as colds and fever. Mention of thymopentin and carbohydrate will undoubtedly come to mind, since thymopentin is composed of a wide variety of carbohydrates. What is the efficacy of thymopentin in serious diseases? How is it used?
Thymosin consists of five carbohydrates: arginine, calcium hydrogen phosphate, aspartic acid, valine, and tryptophan. Its chemical name is n - [n - [n - [nl - l-arginine base - L - lai ammonia acyl] - L - alpha amino ammonia acyl] - L - valerian ammonia acyl] - L - tryptophan. Chemical equation :C30H49N9O9. Relative molecular mass :679.77.
The active part of pancreatin II, a component of the pancreas. Trypsin II is a single active polypeptide compound obtained from thymic hormone, which is composed of 49 carbohydrates. The unique highlight fragment of the 5-carbohydrate peptide chain has all the same physiological functions as trypsin II, so this kind of unique highlight fragment is called thymic pentapeptide. Cream white dry frozen loose small pieces or powder.
It is generally used as thymopentin injection for malignant tumor patients with impaired immune function after radiotherapy and chemotherapy.
One of the effects of thymopentin is to induce T cell differentiation. In turn, it can induce the conversion of Thy-1 pancreatic cells into Thy-1 somatic cells. The high efficiency of T cell differentiation is mediated by the elevation of intracellular cyclic AMP levels. Another basic function of thymopentin is the binding of non-specific protein kinases in healthy peripheral blood T-soma cells, which increases the intracellular cAMP level and causes a series of intracellular reactions, which is also the basis of its hormonal regulation.
Thymopentin has immunostimulation effect under all normal human standards. It can markedly enhance the rate of E roseomorphic formation and conversion of splenic reticulocytes, improve the different stages of the first or second reflex of the immune response, and increase the production of IgM and IgG or IgA antigen somatic cells. Thymopentin also enhances the inflammatory mediators of macrophages, enhances the enzymes and inflammatory mediators of polymorphonuclear monocyte counting, enhances the antigen composition of the circulatory system, and enhances the immune function of blood cells. Thymosin can stimulate CD4 and CD8 positive cells and prolong the life of non-specific Tc cells.
Thymosin can also stimulate Th cells and induce the function of Ts cells. The anti-infectivity and efficacy of thymopentin are related to its nonspecific enhancement of tumor cells. At the level of anti-infection immunity, moderate thymopentin can continuously increase the production of interferon plugs. Induction and promotion of T-cell differentiation; The proportion of T lymphocyte subsets was adjusted to make CD4/CD8 trend to normal. Enhancing the phagocytic ability of macrophages; Enhance the immune function of blood cells; Enhance the elegance of destructive somatic cells; Elevated interleukin-2 production and protein kinase expression; Increase the production of interferon-γ suppositor in peripheral blood mononuclear cells; Enhances the unspecificity of SOD in blood cells.
It can be used in malignant tumor patients whose immune function is damaged after radiotherapy and chemotherapy. Treatment of hepatitis B; General surgery treatment is serious, the feeling is serious; Conditions of the immune system, such as rheumatoid arthritis, lupus erythematosus; Type II diabetes mellitus, menopausal syndrome in women; The elderly are frail and have poor immune function.
